What the body does to a drug, and how that decides the dose.

How the lessons work

Each lesson answers one question about what happens to a drug in the body.

Modules

Start with the first video of module 1, or go straight to the module you need.

All lessons

MODULE 1

ADME overview

3:58

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LESSON 1.1

Absorption

4:03

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LESSON 1.2

Distribution

4:33

▶

LESSON 1.3

Metabolism

2:05

▶

LESSON 1.4

Excretion

3:53

▶

LESSON 1.5

Paracetamol and pharmacokinetics

MODULE 2

Absorption

7:34

▶

LESSON 2.1

Dissolution and solubility

7:50

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LESSON 2.2

Crossing the gut wall

7:32

▶

LESSON 2.3

First-pass metabolism

7:50

▶

LESSON 2.4

Bioavailability

7:31

▶

LESSON 2.5

Food effects

7:33

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LESSON 2.6

Routes and formulations

MODULE 3

Distribution

6:39

▶

LESSON 3.1

Volume of distribution

6:58

▶

LESSON 3.2

Protein and tissue binding

6:32

▶

LESSON 3.3

The blood-brain barrier

6:41

▶

LESSON 3.4

Placenta and breast milk

MODULE 4

Metabolism

8:26

▶

LESSON 4.1

Phase 1 and phase 2 metabolism

8:30

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LESSON 4.2

CYP enzymes

8:51

▶

LESSON 4.3

Prodrugs and active metabolites

8:37

▶

LESSON 4.4

Genes and metabolism

8:09

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LESSON 4.5

Hepatic extraction

MODULE 5

Excretion

7:17

▶

LESSON 5.1

Clearance

7:49

▶

LESSON 5.2

The kidney

9:07

▶

LESSON 5.3

Bile and enterohepatic recycling

7:31

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LESSON 5.4

Clearance, volume and half-life

MODULE 6

Pharmacokinetic models

7:34

▶

LESSON 6.1

The one-compartment model

6:53

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LESSON 6.2

Two compartments

6:40

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LESSON 6.3

Repeated doses

7:12

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LESSON 6.4

Steady state and loading doses

8:10

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LESSON 6.5

Nonlinear pharmacokinetics

7:55

▶

LESSON 6.6

Noncompartmental analysis and population PK

8:03

▶

LESSON 6.7

Noncompartmental analysis

MODULE 7

Prediction

7:58

▶

LESSON 7.1

In vitro ADME assays

7:30

▶

LESSON 7.2

From test tube to human

7:53

▶

LESSON 7.3

From animals to humans

7:38

▶

LESSON 7.4

PBPK models

7:36

▶

LESSON 7.5

Machine learning for ADME

7:33

▶

LESSON 7.6

From molecule to dose