5.17:17Clearance
This lesson defines clearance, shows how it is measured from the dose and the AUC, and why organ clearances add. Ciprofloxacin shows renal and nonrenal clearance and the effect of reduced kidney function.
5.27:49The kidney
This lesson covers filtration, secretion by transporters such as OAT1, OCT2 and MATE, and reabsorption, and creatinine clearance as a measure of kidney function. Metformin shows how secretion and kidney disease set the dose.
5.39:07Bile and enterohepatic recycling
This lesson covers biliary excretion, the transporters that carry drugs into bile, and enterohepatic recycling. Mycophenolate mofetil shows a second peak from recycling, and how ciclosporin lowers exposure.
5.47:31Clearance, volume and half-life
This lesson shows how half-life follows from clearance and the volume of distribution. Midazolam and diazepam show the effect of clearance, and diazepam in obesity shows the effect of volume and the time to steady state.