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  1.1

  Absorption

  This lesson follows a tablet from the stomach into the small intestine, across the gut wall, and into the portal vein.

  3:58
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  1.2

  Distribution

  This lesson covers distribution: only unbound drug leaves the blood, and blood flow, the capillary wall, binding and barriers decide where it goes.

  4:03
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  1.3

  Metabolism

  This lesson covers metabolism: phase 1 and phase 2 reactions, first-pass metabolism in the gut wall and the liver, drug interactions, and prodrugs such as valacyclovir and codeine.

  4:33
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  1.4

  Excretion

  This lesson covers excretion: the kidneys filter, secrete and reabsorb drug in the nephron, and the liver secretes some drugs into the bile.

  2:05
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  1.5

  Paracetamol and pharmacokinetics

  This lesson follows paracetamol (acetaminophen) through absorption, distribution, metabolism and excretion, then shows how each process shapes its plasma concentration curve: Cmax, tmax, AUC, bioavailability and half-life.

  3:53

Next moduleAbsorption